How Long to Bake Lasagna at 350 – (Cooking Guide)

One question often echoes in the minds of home cooks: How long to bake Lasagna at 350°F? Earlier, we have shared a recipe guide on how long to bake Lasagna at 425.

Today, we’re going to figure out how to get that perfect balance of tender noodles, savory filling, and gooey melted cheese.

Join me as we will bake a delicious Lasagna a 350 over temperature, simplifying the process while preserving the essence of a truly comforting dish.

How Long to Bake Lasagna at 350


  • Create fancy lasagna using time-saving shortcuts without compromising on flavor.
  • Bake your lasagna in a cast iron skillet for a rustic and festive presentation at holiday gatherings.
  • Elevate your lasagna with the unexpected addition of pepperoni slices for an extra flavor.
  • Achieve layers of gooey goodness with a blend of ricotta, provolone, and mozzarella cheese.
  • Enjoy the taste of a labor-intensive dish without the hassle; it is perfect for Christmas Eve or your next dinner party.

How Long to Bake Lasagna at 350?

Bake lasagna at 350°F for 45 minutes to an hour, ensuring the noodles are tender and a fork inserted into the center goes through all layers. Allow it to rest for 15 minutes before serving for optimal flavor.

How to Bake Lasagna at 350

To bake lasagna at 350°F, layer oven-ready noodles, cooked ground beef, pepperoni, ricotta, and shredded cheese in a cast iron skillet. Drizzle with sauce, sprinkle salt, and Italian seasoning, then bake for 45 minutes to an hour until the noodles are tender and the cheese is melted.

Bake Lasagna at 350 Recipe

Bake Lasagna at 350 Recipe

Yield: 8 servings
Prep Time: 20 minutes
Cook Time: 45 minutes
Additional Time: 15 minutes
Total Time: 1 hour 20 minutes

Allow it to rest before serving for a simply fancy and delicious dish.


  • 2 lbs ground beef (pre-cooked and seasoned with salt and Italian seasoning)
  • Jarred pasta sauce (of your choice)
  • Oven-ready lasagna noodles
  • Pepperoni slices
  • Ricotta cheese
  • 16 oz provolone and mozzarella shredded cheese
  • Salt
  • Italian seasoning


  • Cast Iron Skillet
  • Oven
  • Fork
  • Knife
  • Spoon


Step 1: Prepare the Pan

  • Preheat your oven to 350°F.
  • Add a thin layer of pasta sauce to the bottom of your cast iron skillet.

Step 2: Layering the Noodles

Layering the Noodles

  • Place a layer of oven-ready lasagna noodles on top of the sauce. Consider doubling up the noodles for a heartier base.

Step 3: Building the Layers

Building the Layers

  • Spread about a third of the pre-cooked ground beef evenly over the noodles.
  • Add a few slices of pepperoni on top of the ground beef. This adds a unique and flavorful twist to the lasagna.
  • Spoon dollops of ricotta cheese evenly across the layer.
  • Sprinkle a generous amount (about 1/3) of the shredded provolone and mozzarella cheese over the entire layer.
  • Repeat these layers until your skillet is nearly full.

Step 4: Seasoning

  • Sprinkle a little salt and Italian seasoning over the layers. This adds depth and enhances the overall flavor.

Step 5: Finishing Touches

Drizzle additional pasta sauce

  • Drizzle additional pasta sauce over the top layer.
  • Sprinkle the remaining shredded cheese on top, covering the entire surface.

Step 6: Bake

  • Place the cast iron skillet in the preheated oven.
  • Bake at 350°F for 45 minutes to an hour or until the lasagna is cooked through and the cheese is melted and bubbly.

Step 7: Check for Doneness

  • Insert a fork into the center to ensure the noodles are tender, and it goes through all the layers.

Step 8: Resting Time

  • Allow the lasagna to rest for at least 15 minutes after removing it from the oven. This helps the juices settle.

Step 9: Serve and Enjoy

Serve and Enjoy

  • Cut into slices and serve. The lasagna will be hot, flavorful, and simply irresistible.


Can I use a different type of meat for this lasagna?

While we used ground beef in this recipe, you can substitute it with ground turkey, chicken, or even a meatless alternative for a vegetarian version.

Are oven-ready lasagna noodles necessary, or can I use regular ones?

Oven-ready lasagna noodles are recommended for convenience. If you prefer regular noodles, you must cook them according to the package instructions before layering them in the skillet.

 What other toppings can I add to make it my own?

Consider adding sautéed mushrooms, spinach, or diced bell peppers. Customize it to your taste and preferences.

Can I use fresh herbs instead of Italian seasoning?

Yes, you can substitute fresh herbs like basil, oregano, and thyme for Italian seasoning. Adjust the quantities based on your flavor preferences.

Why use a cast iron skillet?

A cast iron skillet adds a rustic touch and enhances the overall presentation. It also distributes heat evenly, promoting a delicious crust on the bottom layer of noodles.

How do I reheat leftovers?

To reheat, cover the skillet with foil and warm it in a preheated oven at 350°F until heated through. You can also use a microwave for individual servings.

Can I freeze the lasagna?

Yes, you can freeze the lasagna before or after baking. Wrap it tightly in plastic wrap and aluminum foil. To reheat from frozen, allow it to thaw in the refrigerator overnight and then bake as directed.

Is there a substitute for ricotta if someone doesn’t like it?

Substitute ricotta with cottage cheese or a mixture of cream cheese and sour cream for a different texture and flavor.

Can I use homemade pasta sauce instead of a jarred one?

Homemade sauce can add a personal touch. Ensure it’s thick enough to prevent the lasagna from becoming too watery during baking.


In conclusion, this simply fancy cast iron skillet lasagna is a delightful blend of ease and elegance. By using a few shortcuts like jarred sauce and oven-ready noodles, we’ve created a dish that is both simple to make and incredibly flavorful.

The cast iron skillet adds a rustic charm, making it perfect for holiday gatherings or any special occasion.

The layers of ground beef, pepperoni, ricotta, and gooey melted cheese come together beautifully, creating a lasagna that tastes like it took all day to prepare.

So, next time you want to impress your guests with a dish that’s both simply fancy and delicious, give this cast iron skillet lasagna a try. Your taste buds will thank you, and you might just find a new favorite go-to recipe. Enjoy!

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